Fortune Arterial's story revolves around the male protagonist Kohei Hasekura, who transfers into a prestigious public school in the style of a Western six-year school encompassing junior-high and high school students. The school, named Shuchikan Academy (修智館学院 Shūchikan Gakuin?), is on an island named Tamatsu Island (珠津島 Tamatsushima?) off-shore from mainland Japan, and the only way to get there is by boat. Soon after transferring, he discovers that one of the students from a class next door, Erika Sendo, is a vampire.